Abstract
The aim of the work is the microwave-assisted (MW) synthesis of SERS-active copper nanoparticles (CuNPs) and the core-shell composite based on nanostructured copper layer deposited over CaCO3 microspheres (CaCO3@Cu; 1.4±0.4 μm). The comparison of MW synthesized CuNPs and gold nanoparticles showed the equal orders of magnitude of the Raman enhancement. The temporal stability of CaCO3@Cu samples was found significantly better than that of CuNPs: 4 days vs. 30 min. Stabilizer- and organic solvent-free synthesis of CaCO3@Cu enables to minimize background SERS signal. The applicability of CaCO3@Cu for chemical analysis was showed by detection of antibiotic drug (ceftriaxone) in a range of concentrations which is relevant for practical purposes (5–500 μg/mL).
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