Abstract
Phenyl hydrazine and pyridine-3-carbaldehyde were coupled to form a new Schiff base 3-[(E)-(2-phenylhydrazinylidene)methyl]pyridine(PHMP), followed by the formation of its transition metal derivatives (i.e., Co(II), Cu(II), and Zn(II) complexes). All of them were characterized by physical and spectral methods such as 1H-NMR, IR, elemental analysis, UV-Vis spectra, and conductance studies. Thermal study was carried out with TG/DTA method to understand the degradation pattern of the newly synthesized ligand and its complexes. Antibacterial study was carried out with both the gram-positive (Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermis, Streptococcus pneumonia) and gram-negative bacteria (Pseudomonas aeruginosa, Salmonella typhi, Escherichia coli). The complexes showed medium activity as compared to the standard imipenem.
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