Synthesis, pharmaceutical properties, and in silico study of ZnO@TiO2 nanocomposite

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The use of environmentally friendly production of nanoparticles has recently interest of scientists. The primary goal of this study is to create core–shell nanoparticles zinc oxide @ dioxide titanium (ZnO @ TiO2) for some biomedical application by a two-stage Nd: YAG pulsed laser ablation, the first stage involves laser ablation of a Zinc target to produce ZnO nanoparticles (the core) in colloidal form. Subsequently, in the second stage, TiO2 (the shell) is ablated within the colloidal ZnO Nanoparticles. The transmission electron microscope (TEM) findings approve the synthesis of ZnO @ TiO2, displays an average particle size of 13 nm for ZnO particles, 20 nm of TiO2NPs, and 34 nm of the ZnO@TiO2 NPs. The anti-bacterial efficiency was assessed against the bacterial strains' Bacillus cereus, Proteus mirabilis. Our results discovered inhibition zone of 19 mm and12.50 mm for Bacillus cereus, Proteus mirabilis, correspondingly, when by ZnONPs. Whereas inhibition zone of 20.50 mm and 21.50 mm for Bacillus cereus, Proteus mirabilis, correspondingly, when by TiO2NPs. While with ZnO@TiO2NPs, result was better to 27.50 mm for Bacillus cereus and 24 mm for Proteus mirabilis. The antioxidant efficiency was assessed by DPPH, The results show have strong antioxidant activity for ZnO @ TiO2 core–shell than ZnONPs alone, TiO2NPs alone. Cytotoxicity assay established a significant reduction in cancer cell population pole 72hr. Cytotoxicity of ZnO@TiO2NPs on breast cancer cells was 90.23 %. Computational innovation of TiO2, ZnO and ZnO@TiO2 nanoparticles against breast cancer line gave the highest correlation value and RMSD between ZnO and 6NLV receptors from other nanocomposites.