Abstract
Bioconjugation of nanoparticles is a hot topic of research for a wide range of biological applications, particularly in cancer diagnosis and treatment. In this study, we report the synthesis of glutathione capped CuInS2/ZnS quantum dots (QDs) in an aqueous medium followed by folic acid (FA) modification to produce CIS-ZnS/FA conjugates. The as-synthesized QDs were small, with an average particle diameter of 2.3 nm, and emit in the red region, which was retained even after conjugation with FA. The formation of the conjugates was investigated by ultraviolet–visible (UV–Vis) absorption, photoluminescence (PL) and Fourier transform infrared (FTIR) spectroscopy. The conjugate were then analyzed for their cytotoxicity against both folate receptor (FR) positive (HeLa) and FR negative (A549, C26) cancer cell lines. The results of this study revealed the highly biocompatible nature of the CIS-ZnS/FA conjugates towards both FR positive and negative cancer cell lines and thus they are of potential use in biological applications.
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