Abstract
Objective N-octyl-N '- (2-carboxycyclohexanecarbonyl) -chitosan derivative (OCCC) was successfully synthesized. The analysis of the chitosan derivative by infrared spectroscopy, nuclear magnetic resonance spectroscopy and the like was used to verify whether the synthesis was successful. To construct and characterize chitosan nanoparticles with bovine serum albumin as the model drug. The transmission electron microscopy (TEM), encapsulation efficiency, drug loading and in vitro release of the constructed nanoparticles were investigated. Methods OCCC-BSA-NPs were prepared by ion cross-linking method, and we investigate the release of nanoparticles in vitro. Results The optimum conditions were OCCC:TPP concentration = 10:1, ρ (TPP) = 0.8mg / ml, Time = 40min. Under these conditions, the maximum encapsulation efficiency and drug loading were 91.12% and 4.11%, respectively. The drug- loaded nanoparticles were placed in pH = 7.4 PBS, and the release rate reached about 80% at 10h, and reached 90% at 48h, which achieved the effect of sustained release.
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