Abstract
Artemisidiyne A, a cytotoxic compound isolated from Artemisia lactiflora, exhibits an unprecedented structure consisting of the cis-4,5-dihydroxy-2-cyclopentenone core with 1,3-pentadiynyl and 4-hydroxybutyl side chains. Despite its unique structure and useful biological activity, to our knowledge, its synthesis has never been reported. Here, we report the synthesis of the proposed structure for artemisidiyne A and propose a structural revision of this naturally occurring compound.
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