Recent Progress on Natural and Synthetic Flavanone and its Derivatives

Abstract

<div>Flavanones with various biological and pharmacological activities which</div><div>result from their unique structure, a chiral center at C2 and a single bond between C2-</div><div>C3, are considered as a special subgroup of flavonoids. These naturally occurring</div><div>compounds with anticancer, antibacterial, anti-inflammatory activity, as well as</div><div>building blocks and intermediates for organic synthesis have attracted organic and</div><div>medicinal chemists’ attention. Widespread and at the same time interesting application</div><div>of flavanones in different fields of chemistry and pharmacology, reveals increasing</div><div>interests in their syntheses from different synthetic methods. In addition, there are</div><div>many articles published every year about natural flavanones and their novel derivatives</div><div>from different natural sources and study of their biological activities is also proof of</div><div>their priority. As a result, herein we have studied recent progresses about flavanones</div><div>from different aspects such as their: various synthetic methods, different derivatives,</div><div>biological activities, natural sources reported in articles from 2015 to late 2020.</div>