Abstract
A concise and efficient synthesis of the macrolactone core of migrastatin, a new natural product with potent anticancer properties, has been achieved. The key features of our synthetic strategy encompass a Lewis acid catalyzed diene aldehyde condensation (LACDAC) to install the three contiguous stereocenters and the trisubstituted ( Z)-double bond of migrastatin, and a ( E)-selective ring-closing metathesis (RCM) to construct the macrocycle.
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