Synthesis of the five peptide derivatives needed to build the sequence corresponding to 1-30 of human epidermal growth factor (h-EGF).

Song Yuh Shin,Yukihiko Kaburaki,Masanori Watanabe,Eisuke Munekata

doi:10.1271/bbb.56.399

Synthesis of the five peptide derivatives needed to build the sequence corresponding to 1-30 of human epidermal growth factor (h-EGF).

Song Yuh Shin, Yukihiko Kaburaki + Show 2 more

https://doi.org/10.1271/bbb.56.399

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Journal: Bioscience, biotechnology, and biochemistry	Publication Date: Jan 1, 1992
Citations: 3	License type: free

Affiliation: Institute of Applied Biochemistry, University of Tsukuba

#Human Epidermal Growth Factor #Epidermal Growth + Show 8 more

Abstract
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Abstract

For the classical solution synthesis of human epidermal growth factor (h-EGF), five protected peptide derivatives, Boc-Leu-Asp(OcHex)-Lys(Cl-Z)-Tyr(Br-Z)-Ala-OH (5), Boc-Val-Cys(MeBzl)-Met-Tyr(Br-Z)-Ile-Glu(OcHex)-Ala-OH (12), Boc-Tyr(Br-Z)-Cys(MeBzl)-Leu-His-Asp(OcHex)-Gly-OH (18), Boc-Cys(MeBzl)-Pro-Leu-Ser(Bzl)-His-Asp(OcHex)-Gly-O H (23) and Boc-Asn-Ser(Bzl)-Asp(OcHex)-Ser(Bzl)-Glu(OcHex)-OH (28) were synthesized to build up the sequence corresponding to 1–30.

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