Synthesis of substituted-borane adducts of amines and amino acids. The crystal structure of pyridine- N-ethylcarbamoylborane

Abstract

Substituted-borane adducts of amines and α-amino acids, pyridine- N-ethylcarbamoylborane ( 1), (carboxy or cyano)-dihydro[{1-(R)-2-amino-2-oxoethyl] amino}boron] ( 2a– g) (R=CH 2Ph, CH 2PhOH, CH 3, CH(C 2H 6) and N-[(trimethylamineboryl)-carbonyl]-{(3, 4-dihydroxyphenyl)- l-alanine}-methylester ( 3) are synthesized in 63–93% yields. All compounds were characterized by elemental analysis, 1H, 11B and 13C NMR and IR spectroscopy. Additionally, the structure of compound 1 was determined by single crystal X-ray diffraction.