Abstract
Functionalized allylsilanes 1– 5 and aldehydes 6– 8 undergo Lewis-acid mediated ring closure to afford 2,3,5- or 6-substituted tetrahydropyrans ( 8– 15 ) and 2,3-substituted octahydrochromenes ( 16a– b ) with excellent stereoselectivity. According to DFT calculations the high stereoselectivity arises from electronically induced steric effects occurring in the key-intermediate of the cyclization.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
