Abstract
Cyano-5,6-dimethylpyridazin-3-ylthio)-N-(4-substituted-sulfamoyl)phenyl)acetamides 4a-c, were prepared by reaction of 4-Cyano-5,6-dimethylpyridazine-3(2H)-thione 3 with N-Chloroacetylsulfanilamides in the presence of sodium acetate, which were cyclized with piperidine to afford the corresponding thieno(2,3-c)pyridazines derivatives 5a-c. Cyclization of compounds 5a-c with triethyl orthoformate furnished the novel pyrimidothienopyridazines7a-c. Also, refluxing of compound 5a with carbon disulfide in pyridine afforded the corresponding pyrimido('4,'5:4,5)thieno(2,3-c)pyridazine derivative 8. S-alkylated products 9, 10 were obtained by the reaction of compound 8 with some halocompounds in ethanol in the presence of base. The antimicrobial activity for all the synthesized compounds was screened.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
