Abstract
4-Chloro acetyl amino sulphamethaoxazole (A1) was synthesized by the reaction of amino sulphamethaoxazole with chloro acetyl chloride, Then refluxed with ammonium thiocyanate to obtain thiazoldine-4-one (A 2) . (A2) was stirred with formaldehyde and various secondary amines to gain 5 novel compounds Mannich bases(A 3-7 ).and 2,5-Disubstituted thiazolidine-4-one (A 8-11) were synthesized by the reaction of substituted benzyldehyd with Compound (A2) . The structure of the synthesized compounds are confirmed by I.R, 1 H-NMR & 13 C-NMR spectra and Some chemical physical data
Highlights
4-Chloro acetyl amino sulphamethaoxazole (A1) was synthesized by the reaction of amino sulphamethaoxazole with chloro acetyl chloride, refluxed with ammonium thiocyanate to obtain thiazoldine-4-one (A2) . (A2) was stirred with formaldehyde and various secondary amines to gain 5 novel compounds Mannich bases(A3-7).and 2,5-Disubstituted thiazolidine-4-one (A8-11) were synthesized by the reaction of substituted benzyldehyd with Compound (A2)
Sulfa drugs represent group of compounds discovered in a conscious search of antibiotics[13], In our previous work, we synthesized some thiazolidinone derivatives from the reaction of sulphamethaxzole with chloro acetyl chloride .and we synthesized and characterized new Mannich bases by refluxing thiazolidine-4-one with formaldehyde and various secondary amines .thiazolidine-4-one react with various aromatic aldehyd to give 2,5-Disubstituted thiazolidine-4-one
Infrared spectrophotometer as KBr disk. 1H-NMR & 13C-NMR spectra were recorded by Ultra shield 300 MHz
Summary
4-Chloro acetyl amino sulphamethaoxazole (A1) was synthesized by the reaction of amino sulphamethaoxazole with chloro acetyl chloride, refluxed with ammonium thiocyanate to obtain thiazoldine-4-one (A2) . (A2) was stirred with formaldehyde and various secondary amines to gain 5 novel compounds Mannich bases(A3-7).and 2,5-Disubstituted thiazolidine-4-one (A8-11) were synthesized by the reaction of substituted benzyldehyd with Compound (A2). (A2) was stirred with formaldehyde and various secondary amines to gain 5 novel compounds Mannich bases(A3-7).and 2,5-Disubstituted thiazolidine-4-one (A8-11) were synthesized by the reaction of substituted benzyldehyd with Compound (A2) .
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