Abstract
Mono- and disubstituted benzimidazoles were synthesized during alkaline hydrolysis or reactions with ethyl chloroacetate of 1-phenyl substituted 4-(1H-benzimidazol-2-yl)-2-pyrrolidinones. The properties of the synthesized ethyl-[2-(1-(substituted phenyl)-5-oxopyrrolidinyl-3-yl)-1H-benzimidazolyl]ethanoates have been investigated and their benzimidazolium chlorides, 1-carboxymethylbenzimidazoles, condensation products of 2-{2-[1-(3-methylphenyl)-5-oxo-3-pyrrolidinyl]-1H-benzimidazol-1-yl}acetohydrazide with various aromatic aldehydes and aliphatic ketones have been obtained.
Highlights
Benzimidazole heterosystems are present in many natural and synthetic biological activity structures and are of great interest in medical chemistry and pharmacology
Mono- and disubstituted benzimidazoles were synthesized during alkaline hydrolysis or reactions with ethyl chloroacetate of 1-phenyl substituted 4-(1H-benzimidazol-2-yl)-2-pyrrolidinones
Benzimidazole derivatives are distinguished for antimicrobial [1,2,3,4], antifungal [5,6,7], antiviral [8], anthelmintic [9, 10], antihypertensive [11], antihistaminic [12], analgesic [13], and anti-HIV [14] actions
Summary
Benzimidazole heterosystems are present in many natural and synthetic biological activity structures and are of great interest in medical chemistry and pharmacology. Benzimidazole derivatives are distinguished for antimicrobial [1,2,3,4], antifungal [5,6,7], antiviral [8], anthelmintic [9, 10], antihypertensive [11], antihistaminic [12], analgesic [13], and anti-HIV [14] actions. Some of benzimidazoles are used in coordination chemistry [15, 16], in optoelectronics [17], etc. The aim of this study was to synthesize new potentially bioactive benzimidazole derivatives or its intermediates containing carboxyalkyl, hydrazone, pyrrole, and dimethylpyrazole fragments
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