Synthesis of silver nanoparticles by green method stabilized to synthetic human stomach fluid.

Ayman Atta,Abdelrahman Ezzat,Hamad Al-Lohedan

doi:10.3390/molecules19056737

Ayman Atta, Abdelrahman Ezzat + Show 1 more

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https://doi.org/10.3390/molecules19056737

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Abstract

Silver nanoparticles (Ag NP) have been attracted much attention in recent years in biomedical applications due to their antimicrobial activity, but their drawbacks include toxicity and instability to aqueous hydrochloric acid solutions. Ag NPs have now been successfully prepared by a simple and “green” synthesis method by reducing Ag+ ions in the presence of modified poly(vinyl alcohol) thiol (PVA-SH) in aqueous acidic solution. In this respect, Ag NPs were stabilized by coating different types of citrate-reduced Ag NPs with different weight ratios (1–3 Wt. %) of PVSH derivatives. The as-prepared Ag NPs were characterized using UV-Visible, high resolution transmission electron microscopy/ energy dispersive X-ray spectroscopy (TEM/EDS), dynamic light scattering (DLS) and X-ray powder diffraction (XRD) combined with Rietveld analysis. The changes in size, shape, and hydrodynamic diameter of Ag NPs after different duration exposure to synthetic stomach fluid (SSF) and1 M HCl were determined using TEM, XRD and UV-Visible analyses. The data indicated that these Ag NPs possessed high stability to SSF for more than 90 days, which was not previously reported in the literature.

Highlights

Production of advanced materials from nanomaterials is the main goal of nanotechnology
The advantages of these methods are the preparation of Ag NPs with high purity and the possibility of a precise particle size control achieved by adjusting the current density or applied potential
The data generated in this study indicated that approximately of 40% of the OH group of PVA were converted to thiol (SH) groups

Summary

Introduction

Production of advanced materials from nanomaterials is the main goal of nanotechnology. Intravenous administration or ingestion of very high doses of colloidal silver in rats results in organ failure and animal death [8,9] Such studies are useful, they may not fully account for the physiological differences between humans and rodents such as the fact that the pH of gastric fluid differs markedly between humans (pH 1.5) and mice (pH 3) [10,11]. This approach may be especially germane since both the synthetic methods and the mode of surface stabilization affect the dependence of surface charge and aggregation behavior of Ag NPs on pH and the ionic environment [12]

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