Synthesis of selenopyrano[2,3‐b]indol‐4(9H)‐ones and their CH arylation

Abstract

AbstractHerein, we disclose the synthesis of selenopyrano[2,3‐b]indol‐4(9H)‐ones and their aryl derivatives using seleno‐pyran ring formation via an in situ‐generated selenide reacting directly with α‐halo‐β‐ynones of substituted indoles providing selenopyrano[2,3‐b]indol‐4(9H)‐ones. Subsequent direct CH arylation of the these compounds by palladium‐catalyzed Heck reaction enables the incorporation of aryl substituents on the selenopyrano[2,3‐b]indol‐4(9H)‐ones scaffolds with moderate yields. This new chemo‐type incorporating an indole ring may be useful for the biological screenings.