Synthesis of Quinoline and Polyhydroquinoline Derivatives Using Phloroglucinol Cored Amino Functionalized Dendritic Polymer as Catalyst

Abstract

AbstractPhloroglucinol cored primary amine‐functionalized G0 dendritic polymer (PHG−G0) was effectively synthesized. The polymer was characterized by different spectroscopic and analytical techniques including Fourier transform infrared (FT‐IR) and Nuclear magnetic resonance (NMR) spectra, Thermogravimetric Analysis (TG‐DTG) and Gel Permeation Chromatography (GPC). The catalytic efficiency of the PHG−G0 was evaluated in the three‐component one‐pot green synthesis of quinoline and four component synthesis of polyhydroquinoline derivatives. Quinoline derivatives were obtained 92 % of yield within 60 minutes in water/ethanol (1 : 1) (v/v) mixture as solvent and polyhydroquinoline derivatives were obtained 90 % of yield within 30 minutes in acetonitrile as solvent under reflux conditions. High amino group capacity and high thermal stability made the PHG−G0 dendritic polymer a good base catalyst. All the quinoline and polyhydroquinoline derivatives were characterized by determining the melting point, Fourier transform infrared (FT‐IR) and Nuclear magnetic resonance (NMR) spectra. The present method is green, efficient, and cost‐effective. Catalyst can be reused up to four reaction cycles without any characteristic loss of its activity.