Synthesis of Quinazolin-4(3H)-ones via a novel approach

Abstract

The present work was designed based on the new multi-component reaction, which forms 2-aryl/alkyl-quinazolin-4(3H)-ones in a one-pot reaction with good to excellent yields (86–97 %) using 2-aminobenzoic acid, organic acid, and ammonium hexafluorophosphate (NH4PF6). The advantages of the presented method include inexpensive and readily available starting materials, simple procedures, and easy workup. In this newly discovered method, ammonium hexafluorophosphate (NH4PF6) was used as a highly efficient reagent and catalyst for quinazolin-4(3H)-ones synthesis. All of the synthesized compounds were characterized by 1H NMR and 13C NMR techniques.