Synthesis of potential antineoplastics by condensation of phthalic anhydride with 4-bis(2-chloroethyl)aminophenylacetic acid

Abstract

Indandione, its enol acetate, and the products of a parallel reaction — a mixture of isomeric acidsE, Z-5, and phthalide — are formed in the reaction of substituted phenylacetic acid with phthalic anhydride in acetic anhydride and triethylamine. 2-Substituted indandione derivatives were obtained.