Abstract
The combination of hydrogels with broad-spectrum antibacterial agents makes it possible to create a universal analogue of tissue dressing material with the necessary properties for the treatment of wounds and ulcers. Chlorhexidine-saturated (0.05%) hydrogels based on polyacrylamide polymers, dextran-grafted polyacrylamide and dextran sulfate-grafted-polyacrylamide copolymers are able to desorb the active substance into the aqueous medium at different rates due to their physicochemical characteristics. Among them in the form of complex therapy it is most beneficial to use the hydrogel based on dextran-grafted polyacrylamide for treatment and prevention of bacterial infection of wounds due to high rates of drug desorption which gives the material antibacterial properties.
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