Abstract

Phosphoramide derivatives 13 and 15 were prepared as analogues of sphinganine-1-phosphate ( 4). Key steps of the synthesis are the alkylation of N-methoxy-N-methlycarboxyamide of the diaminopropanoic acid 7 and the subsequent reduction of the intermediately formed ketone 8 affording the diastereomeric alcohols 9. Deprotection and phosphorylation of 9 lead to the desired products 13 and 15.

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