Abstract
Abstract New aminoacyl-adenylate analogs (aa-AMPNs), in which the oxygen atom of the mixed anhydride bond of aminoacyl-adenylates is replaced by an NH group, were synthesized by the reaction of an adenosine 5′-phosphoramidite derivative with appropriately protected amino acid amides. Among various reagents studied for activation of the 5′-phosphoramidite derivative, 5-(4-nitrophenyl)-1 H -tetrazole was found to give N -acyl phosphoramidate derivatives in good yields.
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