Synthesis of Phosphate Esters by Using Diphenyl Ditelluride as Organocatalyst

Abstract

AbstractWe report a protocol for the synthesis of new dialkyl(1‐(organolthio)naphthalen‐2‐yl)phosphates and derivatives via a dehydrogenative phosphorylation reaction between functionalized naphthols and H‐phosphonates. Diphenyl ditelluride was employed as an organocatalyst and sonochemistry as an alternative energy source. The reaction conditions were defined through a factorial design approach, and the best condition provided the synthesis of dialkyl(1‐(organolthio)naphthalen‐2‐yl)phosphates in yields that varied from 51–98 % under ultrasound irradiation after 2 h of sonication. The synthetic protocol was also effective for phenol and thiophenol starting materials. All products were characterized by state‐of‐the‐art spectroscopic and spectrometric techniques.