Abstract
α-Fluorinated organosilanes Me 3 SiCF 2 X serve as versatile reagents for the synthesis of organofluorine compounds. Most reactions start from Lewis base activation of carbon–silicon bond through the intermediacy of five-coordinate siliconate species. Interaction of these silanes with suitable electrophiles leads to products of nucleophilic fluoroalkylation; an alternative pathway involves generation of difluorocarbene. These reagents can also be considered as equivalents of difluoromethylene radical anion and bis(carbanion) when carbon–heteroatom bond C–X is activated.
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