Synthesis of oligonucleotides bearing the non-standard bases iso-C and iso-G. Comparison of iso-C- iso-G, C-G and U-A base-pair stabilities in RNA/DNA duplexes

Christopher Roberts,Rajanikanth Bandaru,Christopher Switzer

doi:10.1016/0040-4039(95)00603-a

Synthesis of oligonucleotides bearing the non-standard bases iso-C and iso-G. Comparison of iso-C- iso-G, C-G and U-A base-pair stabilities in RNA/DNA duplexes

Christopher Roberts, Rajanikanth Bandaru + Show 1 more

https://doi.org/10.1016/0040-4039(95)00603-a

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Journal: Tetrahedron Letters	Publication Date: May 1, 1995
Citations: 36

Affiliation: University of California, Riverside

#Deoxy #Base-pair + Show 3 more

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Abstract

The synthesis of iso-cytidine and 2′-deoxy- iso-guanosine phosphoramidites in protected form is described. The synthesis of complementary dodecanucleotides containing a central iso-C- iso-G base-pair was achieved. It is found that the iso-C- iso-G base-pair has comparable stability to a C-G base-pair.

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