Abstract
2-Cyanoethyl phosphate employed as an efficient phosphorylating agent in the synthesis of nucleotide was found to be an excellent catalyst for the conversion of ribonucleosides to their 2', 3'-O-isopropylidene derivatives. This fact has led to the establishment of a novel, single-step conversion of ribonucleosides to 5'-ribonucleotides in a high yield using 2-cyanoethyl phosphate, acetone, pyridine, and dicyclohexylcarbodiimide without isolation of the 2', 3'-O-isopropylidene derivatives.
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More From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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