Abstract
Synthesis of novel pyrazolo[3,4-b]pyridine derivatives in aqueous medium
Highlights
The indole moiety is a well-known heterocycle, an important feature of many natural products and medicinal agents,[1] and has been of continuing interest throughout the research work of the Dedicatee
2,3,3-Trimethyl-3H-indoles 9a-c were synthesized by the reaction of the relevant phenylhydrazine hydrochloride 8a-c with isopropyl methyl ketone in a Fischer reaction[25] (Scheme 2)
The malondialdehyde 10c is a new example and its structure rests on the observation of two 1H NMR one-hydrogen singlets at δH 9.75 and 9.78 corresponding to the aldehyde protons and a one-hydrogen signal for the N-hydrogen appearing at δH 13.60
Summary
The indole moiety is a well-known heterocycle, an important feature of many natural products and medicinal agents,[1] and has been of continuing interest throughout the research work of the Dedicatee. Joulec aFaculty of Chemistry, University of Urmia, Urmia 57153-165, Iran bSaba College of Higher Education, Urmia 57166-53847, Iran cThe School of Chemistry, The University of Manchester, M13 9PL, UK Email: mehdi.baradarani@gmail.com
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