Synthesis of novel pyrazole derivatives containing tetrahydrocarbazole, antimicrobail evaluation and molecular properties

Abstract

In this research, synthesis sequence of novel pyrazole derivatives was carried out by the reaction of cyclohexanone with phenylhydrazine hydrochloride in acid as solvent [THCZ] [0]. After that, [THCZ] [0] reacted with HgCl2 to prepare compound [1]. Compound [1] was condensate with chloroacetyl chloride in dry DMSO to give α-Chloro-N-(1,2,3,4-Tetrahydrocarbazole) acetamide to give compound [2] that react with para phenylene diamine to give compound [3]. Followed by diazonium salt preparation, this salt reacts with acetyle acetone to give compound [4]. Finally, compound [4] reacted with hydrazine, phenyl hydrazine and substituted phenyl hydrazine to give pyrazole derivatives [5-9]. To identify the most efficient biologically active compounds, the newly synthesized compounds were tested against different microorganisms to evaluate their anti-microbial activities on bacterial strains, gram-positive bacteria, gram-negative bacteria, and fungal strain.