Synthesis of Novel Oxazolidinone Derivatives Bearing Benzo[b]thiophene Moiety and their Antimicrobial Evaluation

Abstract

Literature survey revealed that the oxazolidinone derivatives exhibit pharmacological significance. Thus, by targeting to design new antimicrobial agent, a novel series of oxazolidinone derivatives (11a-t) having benzo[b]thiophene moiety were synthesized. Chemical structures of the synthesized compounds were confirmed through spectroscopic techniques such as IR, NMR and Mass spectroscopy. All the new synthesized compounds were subjected to in vitro antimicrobial testing by estimating zone of inhibition toward Gram-positive pathogens like Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923 and Streptococcus pyogens ATCC 8668.