Abstract
A novel series of 2/6-aryl/heteroaryl substituted-N-(6-(trifluoromethyl)pyridin-2-yl)pyrimidin-4-amine analogues have been synthesized from dichloropyrimidines by an initial substitution followed by Suzuki coupling with boronic acids or esters. This sequence has made the process cost-effective. Thus, in the present work, commercially sourced 2,4 and 4,6-dichloropyrimidines were initially condensed with 2-amino-6-trifluoromethylpyridine in the presence of NaH to obtain N-arylated pyrimidin-4-amine analogues. These were transformed to various novel pyrimidine derivatives 2a-2l & 3a-3l via Suzuki coupling using various substituted aryl/heteroaryl boronic acids or boronic esters. These newly synthesized compounds have been confirmed by 1H NMR, 13C NMR & MS analysis.
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