Abstract
Abstract: The hydrazide compound ( 2 ) was synthesized starting from 1-(2-fluorophenyl)piperazine via two stage. The reaction of compound ( 2 ) with different alkyl(aryl)isothiocyanates afforded the corresponding compounds ( 3a-c ) . 1,3-Thiazolidine derivatives ( 4a-c ) were synthesized from the treatment of ( 3a-c ) with ethyl bromoacetate. Mannich bases ( 6a-d ) were yielded the treayment of ( 5a-c) with various suitable amines in the exictence of formaldehyde. Compound ( 3 ) derivatives were converted to 1,2,4-triazole as the starting material of fluoroquinolone analogues ( 11a-c ). Finally synthesized compounds were examined their biological properties and some of these showed potent activity.
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