Synthesis of Novel Anti-Inflammatory and Antimicrobial Agents via Ugi-4CR and its Evaluation

Abstract

Article history: Received on: 03/02/2013 Revised on: 20/02/2013 Accepted on: 05/03/2013 Available online: 30/03/2013 An efficient and rapid synthesis of novel anti-inflammatory and antimicrobial agents using 4-aminoantipyrine, nicotinic acid, ethylisocyanoacetate and substituted aldehydes via Ugi four component reaction (Ugi-4CR) protocol under microwave irradiation in presence of Fluorite as an efficient catalyst. The microwave synthesis route afforded better yields with shorter reaction time. The novel heterocycles were characterized on the basis of IR, H NMR and Mass spectral analysis. All the synthesized molecules 5 (a-h) were examined for their potential in-vivo Anti-inflammatory activity on Wistar Albino rats using a standard reference drug, Indometacin. The synthesized compounds were also screened for their potent in-vitro Antimicrobial activity using few Grampositive and Gram-negative bacteria against a reference antibiotic, Ampicillin and Streptomycin.