Abstract
An expedient, cost-effective and metal-free green protocol has been developed for the preparation of 3-aminoimidazopyridines by the three-component reaction of arylglyoxal monohydrates, aromatic amines and 2-aminopyridines. This multicomponent reaction was executed under microwave irradiation in presence of catalytic amount of molecular iodine in ethanol, involving the formation of three new CN bonds via imine intermediate. Environmentally benign catalyst, eco-friendly medium, good yields, short reaction time and purification by simple crystallization are some distinguished features of this protocol. In addition, presented method is sustainable since produced water only as by product, avoidance of toxic catalyst and good amenability with principle of green chemistry.
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