Synthesis of novel β-lactams: Antioxidant activity, acetylcholinesterase inhibition and computational studies

Abstract

A convenient synthesis of some novel β-lactam derivatives with interesting pharmacological activities was described. Some of the synthesized compounds exhibited excellent antioxidant activity and showed acetylcholinesterase inhibition. Theoretical studies were carried out on the most potent compounds 5a and 5b to compare their potential interaction with crystal structure of recombinant human acetylcholinesterase in complex with Donepezil (PDB ID: 4EY7) and binary complex of native hAChE with Donepezil (PDBID:6O4W). The comprehensive theoretical and experimental mechanical studies of compounds 5b were compatible with its FT-IR, 1H NMR,13C NMR and Mass spectral data. The optimized molecular structure and the harmonic vibrational frequencies were examined DFT/B3LYP/6–31G(d) and Hartree-Fock HF/6–31G(d) energies and the difference in bond length and energies between compounds 5a and 5b was confirmed via theoretical studies.