Synthesis of New Pyrazoline Derivatives and Its Antimicrobial and Antioxidant Activities

Abstract

Resistance gained by microorganism to conventional antimicrobial agents has lead to the development of new antimicrobial agents against pathogenic microbes. Chalcones and their derivatives proved to be an important molecular scaffold for the search of new pharmaceutically active molecules. Among the various derivatives of chalcones, synthesis of pyrazolines has gained major attention due to their promising biological activities such as anticancer, antimicrobial, antidepressant, immunosuppressive, anti-inflammatory, etc.1−8 Many studies revealed that incorporation of pyrazole moiety into various heterocyclic ring systems gives worthwhile molecules from the biological point of view.9−11 Several marketed drugs such ascelecoxib12 and rimonabant13 contains pyrazole as their core molecular unit.14,15