Abstract
1,3-dipolar cycloaddition of arylnitrile oxides with allyl ester prepared from eugenol afforded new chiral isoxazolines in good yields. The chemical structure of this compounds was characterized by 1H NMR,13C NMR, 2D NMR and TOF-MS analysis. All the cycloadducts were obtained through a regiospecific and stereospecific pathway and all cases, only one isomer was isolated, as established by unambiguous NMR analysis
Highlights
Heterocyclic; compounds have a wide range of applications in synthetic organic chemistry
The combrestatine A-4, analogous 1-3 and the Avicine 4 compound derived from isoxazolines possess anti-cancer activities.[11]
The 1,3-dipolar cycloaddition: of nitrile oxides with alkenes and alkynes afforded isoxazolines, which are used as intermediates for the synthesis of -amino alcohols and alkaloids.[14,15]
Summary
Heterocyclic; compounds have a wide range of applications in synthetic organic chemistry. 1,3-dipolar cycloaddition, arylnitrile oxides, allyl esters, isoxazolines, regiospecific reaction.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
