Synthesis of New Energetic Materials and Ionic Liquids Derived from Metronidazole

Miguel A Romero

doi:10.1155/2016/4705809

Abstract

Simple and efficient synthetic procedures were established for the preparation of new energetic covalent compounds, salts, and protonated ionic liquids based on the readily available antimicrobial agent metronidazole. Some of these materials exhibit the desirable properties of energetic materials and energetic ionic liquids, such as low vapor pressure, low melting point, good chemical and thermal stability, and high energetic content. For each of the relevant compounds prepared, thermal stability was determined by differential scanning calorimetry. Some of these compounds may be considered promising precursors of pharmaceuticals such as antimicrobial, antiparasitic, antifungal, antineoplastic agents, or enzyme inhibitors.

Highlights

Interest in energetic ionic liquids (EILs) has grown exponentially in the last few years as a result of their application in various areas of research such as electrochemistry, separation science, chemical synthesis, and catalysis [1, 2]
The main thrust for the development of new EILs has been their substitution as propellants for such compounds as hydrazine and derivatives thereof, which at present pose various problems such as corrosion, safety in handling and storage, high melting points, and the need to use plasticizers [5]
One area of development of new EILs is the use of imidazole-based compounds for the preparation of salts, either protonated or alkylated, that exhibit the physical and chemical properties typical of energetic materials [7,8,9,10,11,12,13]

Summary

Introduction

Interest in energetic ionic liquids (EILs) has grown exponentially in the last few years as a result of their application in various areas of research such as electrochemistry, separation science, chemical synthesis, and catalysis [1, 2]. The main thrust for the development of new EILs has been their substitution as propellants for such compounds as hydrazine and derivatives thereof, which at present pose various problems such as corrosion, safety in handling and storage, high melting points, and the need to use plasticizers [5]. One area of development of new EILs is the use of imidazole-based compounds for the preparation of salts, either protonated or alkylated, that exhibit the physical and chemical properties typical of energetic materials [7,8,9,10,11,12,13]

General Information

Compound Preparation

Results and Discussion

Conclusion