Abstract
Polyvinil alcohol (PVA) polymer can be used as matrix to be mixed with collagen in the subtance of primary wound dressing material to cover wound that prevents growth of bacteria and enhanced tissue formation. Collagen fiber is fragile, so important to combined with PVA to obtain better mechanical properties. The PVA-collagen fibers are prepared in aqueous solutions with PVA (10%) and collagen concentration (1% and 2%) using electrospinning method and the effect of voltage 15 kV, 19 kV, and 23 kV. Analysis of functional groups show that the presence of identical compounds produced and new functional groups are not formed. SEM data show that the effect of variation of voltage and collagen concentration on the resulting morphology of fiber. PVA-collagen 2% fibers produce continuous fibers, has a diameter 284-426 nm, thickness 0.0324-0.0483 mm and has a high percent of elongation so it can be used as a wound dressing material.
Highlights
Over the past few decades, the development of nanotechnology has grown very rapidly and has an impact on developments in various industries
The Poly Vinil Alcohol (PVA)-collagen solution was made into 2 ie 1% collagen solution dissolved into 10% PVA solution and 2% collagen solution dissolved into 10% PVA solution
The synthesis of PVA-collagen fibers can be conducted by electric spinning method by giving two variations namely variation of concentration of collagen solution of 1 % and 2 % and variation of voltage equal to 15 kV, 19 kV, and 23 kV
Summary
Over the past few decades, the development of nanotechnology has grown very rapidly and has an impact on developments in various industries. One of the materials produced using the principle of nanotechnology is nanofiber Nanofiber has advantages such as high surface ”Synthesis of Nanofiber from Poly Vinil Alcohol (PVA) Collagen ...”: Sudirman, et al.│55. Electric spinning fiber results can be applied in biomedical fields such as wound dressing materials [2]. The research on the synthesis of fiber-based composite PVAcollagen using electric spinning method can be applied as a wound dressing material. Manufacturing nanofiber from natural polymer solution such as collagen is not possible because of its mechanical properties has many deficiencies compared to synthetic polymers, making it difficult to be processed using electric spinning. Polyvinyl alcohol (PVA) is a synthetic resin used as a support material for tissue engineering because it has stable, flexible, non-toxic, non-carciogenic, and elastic mechanical properties [6].
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