SYNTHESIS OF MOLECULARLY IMPRINTED POLYMERS (MIPS) USED FOR ESTIMATION OF BETAMETHASONE DISODIUM PHOSPHATE (BMSP) USING DIFFERENT FUNCTIONAL MONOMERS

Al-Abbasi & Et Al

doi:10.36103/ijas.v51i1.947

Abstract

Betamethasone sodium phosphate (BMSP) selective molecularly imprinted polymers(MIPs) were based on ion-pair by prepared four polymers(MIPs) using BMSP as the template a well as (Acryl amide) (AAM), 2-Acrylamido-2-Methyl-1-Propane sulphonic Acid (2-AAMMPSA as monomer, used N,N-ethylenebismethacrylamide (EBMAA) ,ethylene glycol dimethacrylate ethylene glycol(EGDMAC), N, N-methylene bisacrylamide (NNMBAAM)) as cross linker and used benzoyl peroxide as initiator . NIPs prepared by using the same composition of MIPs except the template (BMSP). The MIPs were prepared using variation ratio of monomer and cross linker .These MIPs applicate as solid phase extraction for determination BMSP in pharmaceutical preparation used UV as detector .the results gave good response, where the reconstruction percentage (Rec%) value of BMSP drug took the range (99.058149 % - 101.887004 %), and the relative standard deviation (RSD%) value took the range (0.224149 % - 0.743651 %) for standard solution and Rec% took values of (98.400035 - 99.404218) %, and RSD% took values of (0.572589 - 1.012777) % of BMSP drug for the Betamethasone sodium phosphate pharmaceutical.

Highlights

Betamethasone sodium phosphate (BMSP) is the representative of the synthetic steroids, belonging to the glucocorticoid class[1], Chemically its is known as 9- ( -Fluoro-11β,17-dihydroxy-16 β-methyl-3,20-dioxopregna-1,4-diene-21-yl), White or almost white powder, very hygroscopic molecular formula (C22H28FNa2O8P), The chemical structure of betamethasone sodium phosphate is shown in figure. 1, its is Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride, Natural and synthetic glucocorticoids are known to be highly effective drugs for the treatment of inflammatory diseases
Dioxopregna-1,4-diene-21-yl), White or almost white powder, very hygroscopic molecular formula (C22H28FNa2O8P), The chemical structure of betamethasone sodium phosphate is shown in figure. 1, its is Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride, Natural and synthetic glucocorticoids are known to be highly effective drugs for the treatment of inflammatory diseases
Using Novel magnetic molecularly imprinted polymer nanoparticles (MMIPs) using methacrylic acid as a functional monomer, MAEMA as a cross-linker, and betamethasone as a template The Fe3O4 nanoparticles were encapsulated with a SiO2 shell and functionalized with ACH@CH2 and

Summary

Introduction

Betamethasone sodium phosphate (BMSP) is the representative of the synthetic steroids, belonging to the glucocorticoid class[1], Chemically its is known as 9- ( -Fluoro-11β,17-dihydroxy-16 β-methyl-3,20-dioxopregna-1,4-diene-21-yl), White or almost white powder, very hygroscopic molecular formula (C22H28FNa2O8P), The chemical structure of betamethasone sodium phosphate is shown in figure. 1, its is Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride, Natural and synthetic glucocorticoids are known to be highly effective drugs for the treatment of inflammatory diseases. 1, its is Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride, Natural and synthetic glucocorticoids are known to be highly effective drugs for the treatment of inflammatory diseases They are widely administrated to relieve joint pain,symptoms of inflammatory skin problems and inflammation due to arthritis, asthma and rhinitis in clinical , It is active in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant, inflammatory bowel disease, reactive airways disease, and respiratory distress syndrome in preterm infants and pruritus in corticosteroidresponsive dermatoses, ulcerative colitis, lupus erythematosus, acute leukemia[14,18], BMSP was estimated in several ways, including the use of UPLC / MS / MS [6, 11] , and was estimated using a voltammetric method [19], and the use of prepared and modified silica compounds [13], Methods were developed using (RP-HPLC) [12,13], this study was formulation and evaluation of betamethasone sodium phosphate (BMSP). MMIPs were prepared by using methacrylic acid as a functional monomer, N,N-pphenylene bismethacryl amide as a crosslinking agent and betamethasone as template [8] There are a variety of ion selective electrode determined drugs that depended on MIPs as recognition membranes like ibuprofen[18], warfarin [1], phenytoin [3] and metronidazole benzoate [2].

Objectives

Methods

Results