Abstract
We describe the synthesis of a novel cyclopropyl analogue of arachidonic acid via a convergent synthesis that employed methyl (1R,2S)-2-formylcyclopropanecarboxylate in conjunction with the ylide from (3Z,6Z)-pentadeca-3,6-dienyl(triphenyl)phosphonium iodide. This compound was designed to inhibit the enzyme 5-lipoxygenase after reaction to form a putative α-cyclopropylmethylene radical.
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