Abstract
The first synthesis of a series of ketones naturally occurring in E. pallida is described. The natural distribution of these ketones among different Echinacea species is also reported.
Highlights
Echinacea angustifolia, Echinacea pallida and Echinacea purpurea are the main medicinal Echinacea species and have long been used to treat infections, aid in wound healing, and enhance the immune system [1]
In 2005, Echinacea products ranked among the top botanical supplements sold in the United States
Treatment of rhinoviruses has been the focus of several studies, a number of which have failed to show the efficacy of Echinacea [2]
Summary
Echinacea pallida and Echinacea purpurea are the main medicinal Echinacea species and have long been used to treat infections, aid in wound healing, and enhance the immune system [1]. Removal of the ketal protection group (PPTS, water) provided ketone 2 in 15% overall yield from 7. The distribution of these two ketones in accessions of six species of Echinacea (E. angustifolia, E. purpurea, E. pallida, E. sanguinea, E. simulata and E. tennesseensis) was determined by HPLC.
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