Abstract
Mannostatins A and B, along with the respective enantiomer and diastereoisomer having the ( S)-sulfinyl function, were synthesized from myo-inositol. Inhibitory activity of the synthetic compounds against jack bean α-mannosidase was measured, revealing that the 4-aminocyclopentane-1,2,3-triol structure plays a major role in interaction with the enzyme. Mannostatins A and B, together with the respective enantiomer and diastereoisomer having the ( S)-sulfinyl function, were synthesized from myo-inositol. Inhibitory activity of the synthetic compounds against jack bean α-mannosidase was measured.
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