Abstract
FCE28833 inhibits kynurenine 3-hydroxylase thereby elevating levels of kynurenic acid, an endogenous excitatory amino acid receptor antagonist. It may have therapeutic value in treating diseases linked to hyperfunction of excitatory amino acid receptors. A short and highly enantioselective synthesis of FCE28833 features an asymmetric intermolecular Stetter reaction catalyzed by the N-heterocyclic carbene E.
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