Abstract
AbstractThe preparation and thorough characterization of a variety of (arylmethylene)phosphonate ester derivatives (S1–S7) as well as derived geminal bisphosphonate (BP) ester ligands (L1–L7) is presented. Subsequent complexation reactions of CaCl2 with selected BPs (L1–L3) and a known aliphatic tetrakisphosphonate ester (L8) yield the respective Ca(II) coordination compounds [Ca(H2O)2(L1‐‐L3)2]Cl2 (C1‐‐C3) and [Ca(L8)Cl2]n (C4) for potential future application as multi‐delivery systems in osteoporosis treatment. Obtained SCXRD and 1H DOSY‐NMR data provide a detailed insight into their solid‐ as well as solution‐state structures extending the so far scarcely found X‐ray studies on geminal BP‐supported Ca(II) complexes.
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