Synthesis of Dendrimeric Tumor-Associated Mucin-Type Glycopeptide Antigens

Abstract

Tetravalent tumor-associated peptide and glycopeptide antigens representing partial sequences of the tandem repeat of mucin MUC4 and carrying the tumor-associated Tn saccharide side chain were synthesized on a di-lysyl-lysine core linked to the solid phase. The methodology was extended to the synthesis of an octameric tandem repeat glycopeptide of the particularly relevant tumor-associated mucin MUC1.