Abstract
A selective exchange reaction of the symmetrical acetal 5a with protected cysteine readily provided the hemi-thioacetals 9a and 11a related to leukotriene-E4. Use of acetylene-bis-(diethyl acetal) 12 led to a facile synthesis of the title compound 17a. Its corresponding hexahydro analogs displayed marked antagonist activity against LT-C4 induced contractions on isolated guinea pig lung parenchyma.
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