Abstract
Two pH-sensitive Glycopolymers with the same components but with different construction tailored biotin functionalities were developed for controlled release of bortezomib (BTZ).The initiator brominate biotin and glyco-monomer were synthesized precedently to produce the block-and random-biotinylated poly (2-Gluconamidoethyl methacrylate)-poly (2-Diethylaminoethyl methacrylate) (block/random Biotin-PGAMA-PDEA) via atom transfer radical polymerization (ATRP). The construction and composition of compounds and polymers were characterized by 1H NMR Spectroscopy. The block copolymer self-assembled into micelle according to the pH-response ability of the copolymer while the random one did not under certain conditions.
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