Abstract
ABSTRACT Biologically active chalcones were synthesized via Claisen-Schmidt condensation of aldehydes with different ketones in solvent-free conditions using H 5 PMo 10 V 2 O 40 supported on SiO 2 as a reusable heterogeneous catalyst with excellent reusability. Keywords: Chalcone, Claisen-Schmidt condensation, mixed addenda, heteropoly acid, heterogeneous catalyst.e-mail: ezzat_rafiee@yahoo.com INTRODUCTION Chalcones belonging to flavonoid family have displayed a broad spectrum of biological activities, among which antimalarial 1 , anticancer 2 , antimitotic 3 , antibacterial 4 , antiADIS 5 , antihyperglycemic 6 activities have been reported. These compounds are of high interest due to their use as a key precursor in the synthesis of many biological important heterocycles such as benzothiazepine 7 , pyrazolines 8 and flavones 9 . Thus, the organic/pharmaceutical chemists worldwide have paid more attention to the synthesis of chalcones. Chalcones could be obtained via Claisen-Schmidt condensation carried out in basic or acidic media under homogenous conditions
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