Abstract
A series of new organometallic binuclear platinum(II) complexes of the type [PtMeCl(Me 2SO) 2(μ-NN)] (NN = H 2N(CH 2) nNH 2 with n = 4, 6, 8, 10, 12; 4,4′-bipyridyl and 1,2- bis(4′-pyridyl)ethane) was synthesized and characterized through elemental analysis, 1H and 13C NMR spectroscopy. The interaction of the mononuclear model complex [PtMeCl(Me 2SO)(Bu nNH 2)] and of the binuclear complex [PtMeCl(Me 2SO) 2(μ-H 2N(CH 2) 6NH 2] with different nucleosides was investigated by 1H NMR spectroscopy, revealing a binding preference toward N 7 position in inosine and guanosine and N 3 in cytidine. Thymidine and uridine are not reactive under the same experimental conditions. Gel electrophoresis experiments indicated that the binuclear complexes containing bridging diamines are able to induce significant conformational changes in the supercoiled form of pUC19 plasmid.
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