Abstract
The synthesis of the 14-amino-6, 7-dihydro-12H-benzo[f]indolo[2, 3-a] quinolizinium chloride (2a) and substituted derivatives is described. The compounds were evaluated as inhibitors of protein kinase CKII and structure-activity relationships were studied. The most potent compound was 14-amino-6, 7-dihydro-12H-4-chlorobenzo[f]indolo-[2, 3-a]quinolizinium chloride (2e) with an IC50 of 0.0064 mM.
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